Offered as a live satellite broadcast, webcast, and telephone audioconference premiering Wednesday, December 21, 2005, from 12:00 p.m.–1:00 p.m. ET, the activity will focus on providing evidence-based educational information and clinical context regarding the efficacy of medications used to treat schizophrenia. The recorded satellite broadcast will re-air from 3:00 p.m.–4:00 p.m. ET. This CE activity will be available as an archived webcast, podcast, and telephone audioconference shortly after the live broadcast, and available as a multimedia CD-ROM in January 2006.

Participation in this activity is free, as is obtaining a CE certificate; however, registration is required. Three forms of registration are accepted:
Fax: View the activity details page at http://www.psychCME.net/cmea.asp?ID=127, print and complete the activity details form, and fax to 240.243.1033
Online: Visit the psychCME TV page at http://www.psychCME.net Phone: Call 877.CME.PROS (877.263.7767)

Statement of Need:
The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial is the most comprehensive independent trial comparing existing treatments for schizophrenia. CATIE was designed so that researchers could gain important information about long-term outcomes and cost-effectiveness of a number of medications already used to treat schizophrenia. Participants were recruited from the community at large and assigned to interventions already in widespread use. Patients were followed for 18 months; if at any time during the trial an assigned medication was ineffective or not well-tolerated, patients were re-randomized to other treatment pathways. Data collection in the study was completed in December 2004 and the first analysis was published in September 2005. The primary outcome measure of CATIE is time to all-cause treatment discontinuation, an important clinical endpoint that reflects both clinician and patient judgements about efficacy and tolerability. Secondary outcome measures of CATIE include symptoms, side effects, neurocognitive functioning, and cost-effectiveness. In this evidence-based psychCME TV activity, CATIE researchers will discuss the Phase 1 and Phase 2 results, and will provide context for clinicians who are responsible for making informed, real-world decisions about treating patients with schizophrenia.

Faculty:
Jeffrey A. Lieberman, MD
Chairman, Department of Psychiatry
College of Physicians and Surgeons, Columbia University
Director, New York State Psychiatric Institute
Director, Lieber Center for Schizophrenia Research
Psychiatrist-in-Chief at New York Presbyterian Hospital & Columbia
University Medical Center, New York, NY

Joseph McEvoy, MD
Associate Professor
Department of Biological Psychiatry
Duke University Medical Center - John Umstead Hospital
Butner, NC

psychCME Moderator:
Prakash S. Masand, MD
Consulting Professor of Psychiatry
Duke University Medical Center
Durham, NC

Learning Objectives:
At the end of this CE activity, participants should be able to:
- Assess the efficacy of the various treatments in the CATIE trial.
- Apply a contextual framework to the Phase 1 and Phase 2 CATIE results.
- Recognize the importance of providing individualized treatment strategies for patients with schizophrenia.

Target Audience:
Physicians, physician assistants, nurse practitioners, nurses, psychologists, social workers, certified case managers, pharmacists, and other healthcare professionals with an interest in mental health.

Credit Information:

CNE Credit (Nurses):
This Educational Activity is presented by CME Outfitters, LLC, which has been approved as a provider of continuing education by the New York State Nurses Association, an accredited approver by the American Nurses Credentialing Center's Commission on Accreditation. It has been assigned code 5UYSJZ-PRV-0487. 1.2 contact hours (Pharmacology)

To receive credit, participants must review all activity materials in their entirety, score 70% or above on a post-test, and fully complete and return both the credit request form and activity evaluation. A certificate or statement of credit will be mailed within 4-6 weeks to all who successfully complete these requirements.

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